Rationalization, in our intended sense of the term, occurs when a person favors a particular conclusion as a result of some factor (such as self-interest) that is of little justificatory epistemic relevance, if that factor then biases the person’s subsequent search for, and assessment of, potential justifications for the conclusion. Empirical evidence suggests that rationalization is common in people’s moral and philosophical thought. We argue that it is likely that the moral and philosophical thought of philosophers and moral psychologists is (...) also pervaded by rationalization. Moreover, although rationalization has some benefits, overall it would be epistemically better if the moral and philosophical reasoning of people, including professional academics, were not as heavily influenced by rationalization as it likely is. We discuss the significance of our arguments for cognitive management and epistemic responsibility. (shrink)

According to Cushman, rationalization occurs when a person has performed an action and then concocts beliefs and desires that would have made it rational. We argue that this isn't the paradigmatic form of rationalization. Consequently, Cushman's explanation of the function and usefulness of rationalization is less broad-reaching than he intends. Cushman's account also obscures some of rationalization's pernicious consequences.

In this book Jonathan Adler offers a strengthened version of evidentialism, arguing that the ethics of belief should be rooted in the concept of belief--that...

In lieu of an abstract, here is a brief excerpt of the content:IRBs Under the MicroscopeJonathan D. Moreno (bio)The spring and summer of 1998 were seasons in the sun for institutional review board (IRB) aficionados. Rarely have the arcana of the local human subjects review panels been treated to so much attention in both the executive and the legislative branches of government, not only at the federal but also at the state level. And it looks as if the attention will (...) continue for some time. The spate of interest is due to a series of coincidences: a powerful House of Representatives subcommittee held hearings after its chairman learned about the IRB system during a previous session on research in underdeveloped communities; the Department of Health and Human Services’s Inspector General (DHHS-IG) released a report on IRBs; the National Institutes of Health (NIH) Office of Extramural Research completed a report on clinical trial monitoring; the National Bioethics Advisory Commission (NBAC) readied a report on research involving persons with mental disorders; the states of Maryland and New York completed studies of research with subjects who lack decision-making capacity; and advocacy groups protested a psychiatric research project involving inner city children.Underlying these proximate causes for the IRB blitz is a growing realization that the already considerable clinical trial enterprise will expand significantly over the next few years. Congress is talking about giving the politically popular NIH half again the budget it currently receives, which in turn will stimulate more commercially supported research. The director of the National Cancer Institute is considering a five-fold increase in the number of subjects enrolled in oncology studies over the next several years. Phase I cancer studies are among the most ethically sensitive, so IRBs will have more work cut out for them if this goal is reached. Adding to the rush of interest in IRBs are the government’s recent apology to the survivors of the syphilis study in Tuskegee, continuing congressional dissatisfaction with the way the Pentagon handled its vaccine distribution during the Gulf War, and the controversy about AZT trials in developing countries.On the HillCongressman Christopher Shays, the moderate Connecticut Republican who has developed an interest in human research issues, convened hearings on human [End Page 329] subjects research and the IRB system on 11 June 1998. Shays chairs the House Government Reform/Human Resources Subcommittee. The committee’s ranking minority member is Edolphus Towns of Brooklyn, NY, who shares Shays’s interest in this area.The immediate rationale for the hearings was the release that day of the DHHS-IG report, Institutional Review Boards: A Time for Reform. The subtitle was changed from A System in Jeopardy apparently after some people in DHHS expressed reservations about its seemingly alarmist tone, but the IG staffers who testified before Shays’s subcommittee insisted that they stood behind the message that the IRB system is in trouble if considerable reforms are not undertaken. Among the factors in the research environment cited as support for the bleak forecast: managed care, commercialization, multi-site trials, high IRB workloads, minimal IRB oversight of approved studies, conflicts of interest, insufficient training of IRB members and investigators, and lack of IRB self-studies (DHHS-IG 1998).As is normally the case for congressional oversight hearings, the first panel of witnesses consisted of executive branch officials, including Eric Meslin, Executive Director of the National Bioethics Advisory Commission, and Gary Ellis, Director of the Office for Protection from Research Risks (OPRR). Shays pressed Ellis on the extent to which OPRR conducts on-site investigations of complaints about abuse of human subjects. Admitting that on-site investigations are rare, Ellis suggested that the agency is inadequately staffed to follow up on complaints as quickly as it might wish. The members of Congress who were present at the hearings generally expressed concern about the DHHS-IG’s findings.The second panel that day, which Shays was unable to attend, set a different tone. Four of the panelists—Paul Appelbaum of the University of Massachusetts at Worcester, Robert Levine of Yale University, Angela Bowen of the Western IRB (a private clinical trials review firm), and I—were invited as authorities on the current condition of the IRB system. Bert Spilker... (shrink)

This interdisciplinary work is a collection of major essays on reasoning: deductive, inductive, abductive, belief revision, defeasible, cross cultural, conversational, and argumentative. They are each oriented toward contemporary empirical studies. The book focuses on foundational issues, including paradoxes, fallacies, and debates about the nature of rationality, the traditional modes of reasoning, as well as counterfactual and causal reasoning. It also includes chapters on the interface between reasoning and other forms of thought. In general, this last set of essays represents growth (...) points in reasoning research, drawing connections to pragmatics, cross-cultural studies, emotion and evolution. (shrink)

When someone presents an argument on a charged topic and it is alleged that the arguer has a strong personal interest and investment in the conclusion, the allegation, directed to the reception or evaluation of the argument, typically gives rise to two seemingly conflicting reactions:I. The allegation is an unwarranted diversion. The prejudices or biases of the arguer are irrelevant to the cogency of the argument. In particular, it is a distraction from the crucial judgment of whether the argument is (...) cogent to press the question of whether the arguer truly holds his conclusion on the grounds that he offers, or whether he believes it on some illicit or suspect basis. (shrink)

The claim that reduction entails grounding (but not vice versa) – called ‘the grounding-reduction link’ – is potentially very important but not clearly correct. After working through a fruitful debate between Gideon Rosen (who maintains the link) and Paul Audi (who maintains its impossibility), I distinguish between what I call ‘strict’ and ‘broad’ reduction. Strict reduction is incompatible with grounding, but broad reduction is not. Thus the link is possible, at least for broad reduction. However, neither strict nor broad reduction (...) entails grounding. Ultimately, there may be a link between grounding and some highly qualified form of reduction. However, the philosophical traction that one might hope to gain for grounding via such a link is considerably diminished if not outright lost. (shrink)

This meticulously edited anthology provides a comprehensive, problems-oriented entree to philosophy. Substantial readings from major classical and contemporary thinkers--featuring many of Hackett's widely acclaimed translations--are supported by a general introduction, engaging introductions to each major topic, and a glossary of important philosophical terms.

Though widely discussed, the hard problem of consciousness (‘the hard problem’ hereafter) is surprisingly difficult to pin down. In fact, one may see that not just a couple of plausible conceptions of the problem exist but rather four do. After providing some background for the hard problem, I present and clarify these four conceptions of it. I close by providing some key considerations for and against each of the four conceptions without passing final judgment on any of them. Ultimately, though, (...) we do need to come to a resolution in so far as one is possible. (shrink)

In this paper we propose an Ontology of Commercial Exchange (OCE) based on Basic Formal Ontology. OCE is designed for re-use in the Industrial Ontologies Foundry (IOF) and in other ontologies addressing different aspects of human social behavior involving purchasing, selling, marketing, and so forth. We first evaluate some of the design patterns used in the Financial Industry Business Ontology (FIBO) and Product Types Ontology (PTO). We then propose terms and definitions that we believe will improve the representation of contractual (...) obligations, sales processes, and their associated documents. A commercial exchange, for instance, involves mutual agreement to reciprocate actions, such as transferring money, performing a service, or transferring goods. (shrink)

Extracorporeal membrane oxygenation (ECMO) is currently reserved predominantly for bridging patients to a different destination therapy, but the use of ECMO as a destination therapy itself (ECMO-DT...

The thirty-fourth volume of The Collected Works of Eric Voegelin consists of Voegelin's Autobiographical Reflections, reprinted from the 1989 edition with additional annotations; a glossary of terms used in Voegelin's writings, illustrated ...

In his Experiments in Ethics, Appiah focuses mostly on the dimension of naturalism as a naturalism of deprivation - naturalism’s apparent robbing us of aspects of the world that we had held dear. The aim of this paper is to remind him of that naturalism has a dimension of plenitude as well - its capacity to enrich our conception of the world as well. With regard to character, we argue that scientific psychology can help provide a conception of character as (...) dynamic, in a way that may preserve many key aspects of eudaimonistic ethics from the situationists’ challenge. With regard to intuition, we address Appiah’s worry that naturalistic explanations of the sources of our intuitions may leave us feeling that those intuitions have been thereby debunked. We suggest that it may be that feeling of debunking that should itself be debunked. (shrink)

_Published Essays, 1966-1985_ includes some of the most trenchant and compelling of Eric Voegelin's work and is an indispensable companion to his Anamnesis and to the fourth and fifth volumes of _Order and History,_ which were prepared for publication during the same period, the last two decades of the author's life. These essays are quintessential Voegelin. Voegelin was an essayist at heart, and the pieces gathered here bear on almost every aspect of his philosophy. They range in subject matter (...) and tone from a scalding critique of the German intellectual establishment during the Hitler period and a satire upon contemporary vulgarian culture to magisterial analyses of immortality, reason, and consciousness. The essays also embrace Voegelin's elaboration of the theory of equivalent experiences and symbolizations over human history and his meditation upon the lure of extremes in the rebellion of magic against reason in various modernist attacks on culture. The scope of Voegelin's work is magnified by the collection's final essay, a touching and profound deathbed reflection on God. Running through all the material is Voegelin's conviction that the truly scientific or philosophical life is ordered through an Anselmian _fides quaerens intellectum,_ a faith in search of understanding. Thus, the assertion that "all men by nature desire to know," which opens Aristotle's _Metaphysics,_ is rightly completed by the words the divine Ground of being. It is the search of the Ground by a mystic philosopher-consciously indebted to such great contemplatives as Plato, Anselm, of Canterbury, jean Bodin, and Henri Bergson-that distinguishes Voegelin's own pilgrimage through time in partnership with God. Nowhere does this come more powerfully and luminously clear than in the pages of _Published Essays, 1966-1985._. (shrink)

The period covered by the material published in this volume marks the transition in Eric Voegelin's career from Louisiana to Munich. After twenty years in the United States, in 1958 Voegelin accepted an invitation to fill the political science chair at Ludwig Maximilian University, a position left vacant throughout the Nazi period and last occupied by the famous Max Weber, who had died in 1920. The themes most prominent in the fourteen items reprinted here reflect the concerns of a (...) transition, not only in a scholar's career, and in the momentous shifts in world politics taking place around him, but also in the development of his understanding of the stratification of reality and the attendant demands for a science of human affairs adequate to the challenges posed by the persistent crisis of the West in its latest configurations and by contemporary philosophy. Several of the items herein originated as talks to a specific organization on problems facing German democratization and the development of a market economy amid the ruins of a fragmented culture and infrastructure in a society without historically evolved institutional supports for a satisfactory social and political order. Accordingly, pragmatic matters occupy a central place in a number of these pieces, especially the overriding question of how Germany could move from an illiberal and ideological political order into a modern liberal democratic one. Those accustomed to the theoretical profundity of Voegelin's writings may find welcome relief in the down-to-earth, commonsensical drift of this material addressed, often, to laymen and businessmen. But, of course, the philosophical subject matter lurks everywhere. It finds full expression in several instances as the controlling context of even the least pretentious presentations. One of the attractions of these essays is what the author brings forward as serviceable elementary guideposts under adverse conditions of intellectual disarray, social decay, and turmoil. (shrink)

_Published Essays, 1940-1952,_ includes some of Eric Voegelin's most provocative and interesting essays. Containing his first publications after he fled Vienna and settled in the United States following Hitler's annexation of Austria, this volume provides eyewitness commentary on the rise of National Socialism from the first days of World War II onward. A major study entitled "Growth of the Race Idea" presents a masterful summary of the two volumes on that subject Voegelin first published in 1933. A related essay (...) of wide interest is entitled "Nietzsche, the Crisis, and the War." Another facet of Voegelin's thought incorporated within this volume of the _Essays_ is his extraordinary analysis of the diplomatic correspondence conducted between the Western powers, the papacy, and the Great Khans, whose breathtaking expansion of the Mongol Empire for a time threatened to extinguish Western civilization itself and resulted in a two-century domination of Russia. Another major study is "The Origins of Scientism," an illuminating analysis of the grounds of much of modern philosophy and of all modern political ideologies. There are also surveys of the state of political theory in the late forties, penetrating studies of utopian thought with essays on Thomas More and Goethe, and a concluding essay that explores the intricacies of "Gnostic Politics"—a familiar theme from Voegelin's contemporaneous _New Science of Politics._ This volume of published essays shows Eric Voegelin at his most accessible best. (shrink)

The mechanistic approach in philosophy of science contributes to our understanding of experimental design. Applying the mechanistic approach to experimentation in computing is beneficial for two reasons. It connects the methodology of experimentation in computing with the methodology of experimentation in established sciences, thereby strengthening the scientific reputability of computing and the quality of experimental design therein. Furthermore, it pinpoints the idiosyncrasies of experimentation in computing: computing deals closely with both natural and engineered mechanisms. Better understanding of the idiosyncrasies, which (...) manifest in terms of a nonstandard role for experimentation, are interesting both for computer scientists and for philosophers of science. Computer scientists can think more clearly about their experimental choices. The role of experimentation elucidated by computer science merits further study from philosophers of science generally, as it highlights a role for experimentation hitherto unrecognized by philosophers: demonstration that activities exist. (shrink)

In this paper we build a prey–predator model with discrete weight structure for the predator. This model will conserve the number of individuals and the biomass and both growth and reproduction of the predator will depend on the food ingested. Moreover the model allows cannibalism which means that the predator can eat the prey but also other predators. We will focus on a simple version with two weight classes or stage and present some general mathematical results. In the last part, (...) we will assume that the dynamics of the prey is fast compared to the predator’s one to go further in the results and eventually conclude that under some conditions, cannibalism can stabilize the system: more precisely, an unstable equilibrium without cannibalism will become almost globally stable with some cannibalism. Some numerical simulations are done to illustrate this result. (shrink)

In the target article Pylyshyn revives the spectre of the “little green man,” arguing for a largely symbolic representation of visual imagery. To clarify this problem, we provide precise definitions of the key term “picture,” present some examples of our definition, and outline an information-theoretic analysis suggesting that the problem of addressing data in the brain requires a partially analogue and partially symbolic solution. This is made concrete in the ventral stream of object recognition, from V1 to IT cortex.

Phyllis Illari and Jon Williamson propose a formulation for a general mechanistic account, the purpose of which is to capture the similarities across mechanistic accounts in the sciences. Illari and Williamson extract insight from mechanisms in astrophysics—which are notably different from the typical biological mechanisms discussed in the literature on mechanisms—to show how their general mechanistic account accommodates mechanisms across various sciences. We present argumentation that demonstrates why an amendment is necessary to the ontology referred to by the general mechanistic (...) account provided by Illari and Williamson. The amendment is required due to the variability of some components in computing mechanisms: the very same component serves as either entity or activity, both between levels and within the same level of the explanatory hierarchy. We argue that the proper ontological account of these mechanistic components involves disambiguation via explicitly indexing them as entities or activities. (shrink)

I defend contextualist solutions to the sorites paradox (according to which solutions vague terms are indexicals) from a recent objection raised by Jason Stanley. Stanley's argument depends on the claim that indexical expressions always have invariant interpretations in "Verb Phrase" ellipsis. I argue that this claim is false.

Thomas Hurka writes, “an anti-theoretical position is properly open only to those who have made a serious effort to theorize a given domain and found that it cannot succeed. Anti-theorists who do not make this effort are simply being lazy, like Wittgenstein himself. His central example of a concept that cannot be given a unifying analysis was that of a game, but in one of the great underappreciated books of the twentieth century Bernard Suits gives perfectly persuasive necessary and sufficient (...) conditions for something's being a game.” In this paper, I show that the conditions that Suits proposes for something's being a game are neither necessary nor sufficient. They fail both ways. (shrink)

A celebrated problem for representationalist theories of phenomenal character is that, given externalism about content, these theories lead to externalism about phenomenal character. While externalism about content is widely accepted, externalism about phenomenal character strikes many philosophers as wildly implausible. Even if internally identical individuals could have different thoughts, it is said, if one of them has a headache, or a tingly sensation, so must the other. In this paper, I argue that recent work on phenomenal concepts reveals that, contrary (...) to appearances, this standard conjunction of externalism about content and internalism about phenomenal character is ultimately untenable on other models of phenomenal character as well, including even “qualia realism.” This would be significant for a number of reasons. The first is patent: it would undermine a primary objection to representationalism. The fact that representationalism is incompatible with the conjunction would be no serious problem for representationalism if no other plausible model of phenomenal character is compatible with it. The second is that the many philosophers who embrace the conjunction would be forced to abandon one of the two views; externalism would be true either of both content and phenomenal character, or of neither. Likewise, those philosophers who have taken a stance on only one of the two internalism/externalism debates would have to be seen as thereby committed to a particular stance on the other. The third reason stems from the fact that qualia realism typically goes hand in hand with internalism about phenomenal character. To the extent that it does, my argument would reveal that qualia realism is itself in tension with externalism about content. This would perhaps be the most surprising result of all. (shrink)

This paper has two goals: first, to show that the footnote and structure of App. 20, to which too little careful attention has been given, ultimately undermine a great many interpretations of Hume’s dissatisfaction with his theory of personal identity; and second, to offer an interpretation that both heeds these textual features and (unlike other interpretations consistent with these features) renders Hume worried about something that would have truly bothered him. Hume’s problem, I contend, concerns the relation, in his genetic (...) explanation of ideas such as that of the self, between (i) the objects of the perceptions along which there is a smooth and uninterrupted progress of thought, and (ii) the contents of the ideas that the mind in such cases sometimes subsequently invents. (shrink)

Based on a conference held in June 2007 at the University of California Santa Cruz.

I argue that, if content externalism is in tension with privileged access to content, then content externalism is also in tension with privileged access to phenomenal character. Content externalists may thus have a new problem on their hands. This is not because content externalism implies externalism about phenomenal character. My argument is compatible with the conviction that, unlike some propositional content, phenomenal character is not individuated by environmental factors. Rather, the argument involves considering in tandem two ideas which have become (...) prominent in the philosophy of mind concerning the introspection of phenomenal character. (shrink)

According to colour irrealism, material objects do not have colour; they only appear to have colour. The appeal of this view, prominent among philosophers and scientists alike, stems in large part from the conviction that scientific explanations of colour facts do not ascribe colour to material objects. To explain why objects appear to have colour, for instance, we need only appeal to surface reflectance properties, properties of light, the neurophysiology of observers, etc. Typically attending colour irrealism is the error theory (...) of ordinary colour judgement: ordinary judgements in which colour is ascribed to a material object are, strictly speaking, false. In this paper, I claim that colour irrealists who endorse the error theory cannot explain how we acquire colour concepts (yellow, green, etc.), concepts they must acknowledge we do possess. Our basic colour concepts, I argue, could not be phenomenal concepts that we acquire by attending to the colour properties of our experience. And, I explain, all other plausible explanations render colour concepts such that our ordinary colour judgements involving them are often true. Given the explanatory considerations upon which the irrealist's position is based, this is a severe problem for colour irrealism. (shrink)

Remember that childhood game “Odds or Evens” you used to play in order to settle important disputes such as who gets the last slice of pizza? There was only one element of skill to that game: trying to figure out what the other person would throw. But that wasn’t easy. If your opponent was savvy, that meant trying to figure out what he thought you were going to throw. And that sometimes meant figuring out what he thought you thought he (...) was going to throw. -/- Philosophers call this “thought attribution,” and top poker players are remarkably good at it. The ability to attribute thoughts to other people is especially important in the No-Limit Texas Hold’em tournaments that have, through television and the Internet, swept the globe in recent years. What is required to succeed in this game is not merely attributing “first-order” thoughts to other players, but attributing to them thoughts about your thoughts about their thoughts. In fact, that’s the minimum. The kind of thinking done by the very best players (T. J. Cloutier, Howard Lederer, and Daniel Negreanu are especially good at it) is much more complex than that. -/- In this paper, I explore the light that recent philosophical work on thought attribution sheds on the kind of thinking that goes on at the expert poker table. The paper should be revealing to poker experts and novices alike. And it should be of interest to philosophers interested in poker or thought attribution. -/- The essay is published in Poker and Philosophy, a volume of Open Court's Popular Culture and Philosophy Series. The goal of the series is to introduce philosophical themes to non-philosophers by way of particular topics of interest (in this case poker). (shrink)

In Davidson's philosophy, one finds a wide variety of rich, provocative, and influential arguments concerning the nature of the mind—that mental states emerge only in the context of interpretation, that belief is "in its nature" veridical, that mental events are physical events, and so on. Most, if not all, of Davidson's conclusions about the mind have their source in discussions about the project of "radical interpretation." They rely upon arguments concerning the conditions on the successful interpretation of a speaker by (...) an interpreter who knows nothing initially about the speaker's language or mental states. But what is the relevance of this activity of radical interpretation? Why should the conditions on succeeding at it illuminate anything about the nature of the mind in general? In this paper, I explore these issues. In particular, I will argue that Davidson's confidence in the relevance of radical interpretation for understanding the mind ultimately depends upon a prior and quite substantive view of the mind. Moreover, it is a view of the mind for which Davidson provides little support. Indeed, the little support Davidson does provide appears to depend itself on the very relevance of radical interpretation. (shrink)

Error theorists about color argue that our ordinary judgments ascribing color to material objects are all false. The error theorist proposes that everything that is so, including the fact that material objects appear to us to have color, can best be explained without ever attributing color to objects (for instance, by appealing to surface reflectance properties, the nature of light, the neurophysiology of perceivers, etc.). The appeal of this view stems in significant part from the prevalent thought that such explanations (...) are strongly suggested by our present scientific conception of the world. Recently, however, Barry Stroud has argued that error theorists cannot successfully even acknowledge, let alone explain, all of the facts that error theorists must acknowledge. In this paper, I shall raise an objection to Stroud's argument. I shall conclude by mentioning one way in which we might develop Stroud's general strategy with more success. (shrink)

Error theorists about color argue that our ordinary judgments ascribing color to material objects are all false. The error theorist proposes that everything that is so, including the fact that material objects appear to us to have color, can best be explained without ever attributing color to objects. The appeal of this view stems in significant part from the prevalent thought that such explanations are strongly suggested by our present scientific conception of the world. Recently, however, Barry Stroud has argued (...) that error theorists cannot successfully even acknowledge, let alone explain, all of the facts that error theorists must acknowledge. In this paper, I shall raise an objection to Stroud’s argument. I shall conclude by mentioning one way in which we might develop Stroud’s general strategy with more success. (shrink)

Barry Stroud is well known as a critic of philosophers who purport to answer, or otherwise deflate, the threat of skepticism of the external world. He is most famous in this regard for his seminal paper on transcendental arguments, in which he argues that the prospects of defeating the skeptic with such arguments typically depend upon an implausible form of verification principle. There he mostly focuses upon Strawson and Shoemaker. But since then, Stroud has addressed strategies taken against skepticism as (...) varied as those proposed by Kant, Moore, Austin, Carnap, Quine, Cavell, Davidson, and Sosa, in each case meticulously articulating precisely why the strategy could not ultimately succeed. It is not surprising, then, that Stroud has come to be thought of as the quintessential skeptic. Epistemologists will be surprised to learn, then, that in several recent papers Stroud now argues that we face no threat of skepticism after all. If he who has been so carefully critical of enterprises that purport to answer, or otherwise deflate, the threat of skepticism has something now to say as to why we face no such threat at all, it is a proposal that comes with good pedigree and perhaps even a presumption in its favor. (shrink)

Quevedo brings together a number of philosophical traditions in the Suenos. One chapter of the thesis examines Quevedo's use of Epicurean dream theory as well as the larger ramifications of the dream setting for the satires. Another chapter analyzes the exact nature of Quevedo's sceptical views and their classical sources with emphasis on the content of El mundo por de dentro. Included is a discussion of the moral philosophy presented in the Suenos, deriving primarily from Stoic sources. In each case, (...) Quevedo reconciles these classical influences with Christian doctrine, leading to a discussion in the thesis as to the exact nature of his Christian beliefs as they are expressed in the Suenos, i.e., whether Quevedo was indeed an existentialist and nihilist as many have labeled him. (shrink)

COVID-19 often manifests with different outcomes in different patients, highlighting the complexity of the host-pathogen interactions involved in manifestations of the disease at the molecular and cellular levels. In this paper, we propose a set of postulates and a framework for systematically understanding complex molecular host-pathogen interaction networks. Specifically, we first propose four host-pathogen interaction (HPI) postulates as the basis for understanding molecular and cellular host-pathogen interactions and their relations to disease outcomes. These four postulates cover the evolutionary dispositions involved (...) in HPIs, the dynamic nature of HPI outcomes, roles that HPI components may occupy leading to such outcomes, and HPI checkpoints that are critical for specific disease outcomes. Based on these postulates, an HPI Postulate and Ontology (HPIPO) framework is proposed to apply interoperable ontologies to systematically model and represent various granular details and knowledge within the scope of the HPI postulates, in a way that will support AI-ready data standardization, sharing, integration, and analysis. As a demonstration, the HPI postulates and the HPIPO framework were applied to study COVID-19 with the Coronavirus Infectious Disease Ontology (CIDO), leading to a novel approach to rational design of drug/vaccine cocktails aimed at interrupting processes occurring at critical host-coronavirus interaction checkpoints. Furthermore, the host-coronavirus protein-protein interactions (PPIs) relevant to COVID-19 were predicted and evaluated based on prior knowledge of curated PPIs and domain-domain interactions, and how such studies can be further explored with the HPI postulates and the HPIPO framework is discussed. (shrink)

This analysis comments on Bernstein’s lack of clear understanding of subjectivity, based on his book, Beyond Objectivism and Relativism: Science, Hermeneutics, and Praxis. Bernstein limits his interpretation of subjectivity to thinkers such as Gadamer and Habermas. The authors analyze the ideas of classic scholars such as Edmund Husserl and Friedrich Nietzsche. Husserl put forward his notion of transcendental subjectivity and phenomenological ramifications of the relationship between subjectivity and objectivity. Nietzsche referred to subjectivity as perspectivism, the inescapable fact that any and (...) all consciousnesses exist in space and time. Consciousness is fundamentally constituted of cultural, linguistic, and historical dimensions. (shrink)

The inaugural collection in an exciting new exchange between philosophers and geographers, this volume provides interdisciplinary approaches to the environment as space, place, and idea. Never before have philosophers and geographers approached each other's subjects in such a strong spirit of mutual understanding. The result is a concrete exploration of the human-nature relationship that embraces strong normative approaches to environmental problems.

Effective clinical practice in a hospital needs current knowledge together with the skills and right attitude; these should be applied continuously. Failure of this system can be due to ignorance or arrogance. We attempted to correct these deficiencies by formulating a set of policies which were enforced from 1962 to 1983. The policies related to the following: intensive care (including asthma, nutrition and organ donation), drug prescribing and resuscitation. We believe that these rules improved patient care and the standards of (...) training; the prescribing policy also saved money. (shrink)